5hpw

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Mode of binding of antithyroid drug, propylthiouracil to lactoperoxidase: Binding studies and structure determination

Structural highlights

5hpw is a 4 chain structure with sequence from Capra hircus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:3CJ, CA, HEM, NAG, NO3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_CAPHI Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).[1]

See Also

References

  1. ↑ Benoy MJ, Essy AK, Sreekumar B, Haridas M. Thiocyanate mediated antifungal and antibacterial property of goat milk lactoperoxidase. Life Sci. 2000;66(25):2433-9. doi: 10.1016/s0024-3205(00)80003-x. PMID:10894086 doi:http://dx.doi.org/10.1016/s0024-3205(00)80003-x

Contents


PDB ID 5hpw

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OCA

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