5i5n

Structural highlights

Function

ML_THOGV Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.^{[1] [2] [3]}

References

1. ↑ Jennings S, Martínez-Sobrido L, García-Sastre A, Weber F, Kochs G. Thogoto virus ML protein suppresses IRF3 function. Virology. 2005 Jan 5;331(1):63-72. PMID:15582653 doi:10.1016/j.virol.2004.10.015
2. ↑ Vogt C, Preuss E, Mayer D, Weber F, Schwemmle M, Kochs G. The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB. J Virol. 2008 Nov;82(22):11446-53. PMID:18768974 doi:10.1128/JVI.01284-08
3. ↑ Buettner N, Vogt C, Martínez-Sobrido L, Weber F, Waibler Z, Kochs G. Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor. J Gen Virol. 2010 Jan;91(Pt 1):220-7. PMID:19812269 doi:10.1099/vir.0.015172-0