5ijv

From Proteopedia

Crystal structure of bovine Fab E03

Structural highlights

5ijv is a 8 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q3T101_BOVIN

Publication Abstract from PubMed

A subset of bovine antibodies have an exceptionally long third heavy-chain complementarity determining region (CDR H3) that is highly variable in sequence and includes multiple cysteines. These long CDR H3s (up to 69 residues) fold into a long stalk atop which sits a knob domain that is located far from the antibody surface. Three new bovine Fab crystal structures have been determined to decipher the conserved and variable features of ultralong CDR H3s that lead to diversity in antigen recognition. Despite high sequence variability, the stalks adopt a conserved beta-ribbon structure, while the knob regions share a conserved beta-sheet that serves as a scaffold for two connecting loops of variable length and conformation, as well as one conserved disulfide. Variation in patterns and connectivity of the remaining disulfides contribute to the knob structural diversity. The unusual architecture of these ultralong bovine CDR H3s for generating diversity is unique in adaptive immune systems.

Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.,Stanfield RL, Wilson IA, Smider VV Sci Immunol. 2016 Jul;1(1). pii: aaf7962. Epub 2016 Jul 14. PMID:27574710^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

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References

↑ Stanfield RL, Wilson IA, Smider VV. Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies. Sci Immunol. 2016 Jul;1(1). pii: aaf7962. Epub 2016 Jul 14. PMID:27574710 doi:http://dx.doi.org/10.1126/sciimmunol.aaf7962

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

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PDB ID 5ijv

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Categories: Bos taurus | Large Structures | Stanfield RL | Wilson IA

5ijv

From Proteopedia

Crystal structure of bovine Fab E03

Structural highlights

Function

Publication Abstract from PubMed

References

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