5u9g

Structural highlights

Function

ARFA_ECOLI Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system.^{[1] [2]}

See Also

• Ribosome 3D structures

References

1. ↑ Chadani Y, Ono K, Ozawa S, Takahashi Y, Takai K, Nanamiya H, Tozawa Y, Kutsukake K, Abo T. Ribosome rescue by Escherichia coli ArfA (YhdL) in the absence of trans-translation system. Mol Microbiol. 2010 Nov;78(4):796-808. doi: 10.1111/j.1365-2958.2010.07375.x., Epub 2010 Sep 24. PMID:21062370 doi:http://dx.doi.org/10.1111/j.1365-2958.2010.07375.x
2. ↑ Garza-Sanchez F, Schaub RE, Janssen BD, Hayes CS. tmRNA regulates synthesis of the ArfA ribosome rescue factor. Mol Microbiol. 2011 Jun;80(5):1204-19. doi: 10.1111/j.1365-2958.2011.07638.x., Epub 2011 Mar 30. PMID:21435036 doi:http://dx.doi.org/10.1111/j.1365-2958.2011.07638.x