5yhu

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Crystal structure of the DNA-binding domain of human myelin-gene regulatory factor

Structural highlights

5yhu is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MYRF_HUMAN Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).[1] Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.[2] Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).[3]

References

  1. ↑ Li Z, Park Y, Marcotte EM. A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF. PLoS Biol. 2013;11(8):e1001624. doi: 10.1371/journal.pbio.1001624. Epub 2013 Aug , 13. PMID:23966832 doi:http://dx.doi.org/10.1371/journal.pbio.1001624
  2. ↑ Li Z, Park Y, Marcotte EM. A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF. PLoS Biol. 2013;11(8):e1001624. doi: 10.1371/journal.pbio.1001624. Epub 2013 Aug , 13. PMID:23966832 doi:http://dx.doi.org/10.1371/journal.pbio.1001624
  3. ↑ Li Z, Park Y, Marcotte EM. A Bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF. PLoS Biol. 2013;11(8):e1001624. doi: 10.1371/journal.pbio.1001624. Epub 2013 Aug , 13. PMID:23966832 doi:http://dx.doi.org/10.1371/journal.pbio.1001624

Contents


PDB ID 5yhu

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OCA

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