6cok

Structural highlights

Function

STU1_YEAST Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for separation of the spindle poles during mitotic spindle formation. May cross-link overlapping antiparallel microtubules in the spindle midzone.^{[1] [2]}

References

1. ↑ Yin H, You L, Pasqualone D, Kopski KM, Huffaker TC. Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle. Mol Biol Cell. 2002 Jun;13(6):1881-92. PMID:12058056 doi:10.1091/mbc.01-09-0458
2. ↑ Pasqualone D, Huffaker TC. STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle. J Cell Biol. 1994 Dec;127(6 Pt 2):1973-84. PMID:7806575 doi:10.1083/jcb.127.6.1973