6dg2

From Proteopedia

Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6

Structural highlights

6dg2 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.96Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, though they are ineffective against other members of the Ebolavirus genus which also cause periodic, lethal outbreaks. Here, we present a crystal structure of a pan-ebolavirus antibody, 6D6, as well as single particle electron microscopy reconstructions of 6D6 in complex with Ebola and Bundibugyo virus glycoproteins. 6D6 binds to the conserved glycoprotein fusion peptide, implicating it as a site of immune vulnerability that could be exploited to reliably elicit a pan-ebolavirus neutralizing antibody response.

Structural Characterization of Pan-ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein.,Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO J Infect Dis. 2018 Sep 10. pii: 5093891. doi: 10.1093/infdis/jiy532. PMID:30203042^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

3 reviews cite this structure

Inducing broad-based immunity against viruses with pandemic potential.

Sette et al. (2022)

2 more

10 other articles

No citations found

References

↑ Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO. Structural Characterization of Pan-ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein. J Infect Dis. 2018 Sep 10. pii: 5093891. doi: 10.1093/infdis/jiy532. PMID:30203042 doi:http://dx.doi.org/10.1093/infdis/jiy532

1 Structural highlights
2 Publication Abstract from PubMed
3 See Also
4 References

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PDB ID 6dg2

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Categories: Large Structures | Mus musculus | Milligan JC | Saphire EO

6dg2

From Proteopedia

Antigen Binding Fragment of the Pan-ebolavirus Monoclonal Antibody 6D6

Structural highlights

Publication Abstract from PubMed

See Also

References

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