6e5d

Structural highlights

Function

LPQN_MYCTU Involved in cell envelope biogenesis. May act as a membrane fusion protein, connecting MmpL transporters with periplasmic proteins, and play a role in cell envelope lipid changes during biofilm maturation.^[1] Is also a virulence factor required for intracellular survival (PubMed:30118682). Associates with CBL, a host ubiquitin ligase, and probably blocks the normal functions of CBL and disturbs CBL-mediated antibacterial activity (PubMed:30118682). Interaction counteracts antibacterial defense but causes a reciprocal enhancement of antiviral defense (PubMed:30118676, PubMed:30118682).^{[2] [3]}

References

1. ↑ Melly GC, Stokas H, Dunaj JL, Hsu FF, Rajavel M, Su CC, Yu EW, Purdy GE. Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis. J Biol Chem. 2019 Oct 25;294(43):15711-15723. doi: 10.1074/jbc.RA119.008781. Epub, 2019 Aug 30. PMID:31471317 doi:http://dx.doi.org/10.1074/jbc.RA119.008781
2. ↑ Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses. Mol Cell. 2018 Aug 16;71(4):637-648.e5. PMID:30118682 doi:10.1016/j.molcel.2018.07.010
3. ↑ Eoh H, Jung JU. Bacterial Protein Reshapes Host Defense toward Antiviral Responses. Mol Cell. 2018 Aug 16;71(4):483-484. PMID:30118676 doi:10.1016/j.molcel.2018.08.006