6ey7

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Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound

Structural highlights

6ey7 is a 4 chain structure with sequence from Hcmva. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:C3W, CL, MN
Gene:UL89 (HCMVA)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TRM3_HCMVA] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation (By similarity).

Contents


6ey7, resolution 2.90Å

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