6fnv

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Solution structure of mule deer prion protein with polymorphism S138

Structural highlights

6fnv is a 1 chain structure with sequence from Odocoileus hemionus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

PRIO_ODOHE Found in high quantity in the brain of animals infected with the degenerative neurological disease known as chronic wasting disease (CWD).

Function

PRIO_ODOHE Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).[UniProtKB:P04156][UniProtKB:P04925]

See Also

Contents


PDB ID 6fnv

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