6h3h

From Proteopedia

Fab fragment of antibody against fullerene C60

Structural highlights

6h3h is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.92Å
Ligands:	GOL, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

The structure of the anti-C60 fullerene antibody Fab fragment (FabC60) was solved by X-ray crystallography. The computer-aided docking of C60 into the antigen-binding pocket of FabC60 showed that binding of C60 to FabC60 is governed by the enthalpy and entropy; namely, by pi-pi stacking interactions with aromatic residues of the antigen-binding site and reduction of the solvent-accessible area of the hydrophobic surface of C60. A fragment of the mobile CDR H3 loop located on the surface of FabC60 interferes with C60 binding in the antigen-binding site, thereby resulting in low antibody affinity for C60. The structure of apo-FabC60 has been deposited with pdbid 6H3H.

Structure of the Anti-C60 Fullerene Antibody Fab Fragment: Structural Determinants of Fullerene Binding.,Osipov EM, Hendrickson OD, Tikhonova TV, Zherdev AV, Solopova ON, Sveshnikov PG, Dzantiev BB, Popov VO Acta Naturae. 2019 Jan-Mar;11(1):58-65. PMID:31024749^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

0 reviews cite this structure

Dissecting the Supramolecular Dispersion of Fullerenes by Proteins/Peptides: Amino Acid Ranking and Driving Forces for Binding to C<sub>60</sub>.

Marforio et al. (2021)

-1 more

1 other articles

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References

↑ Osipov EM, Hendrickson OD, Tikhonova TV, Zherdev AV, Solopova ON, Sveshnikov PG, Dzantiev BB, Popov VO. Structure of the Anti-C60 Fullerene Antibody Fab Fragment: Structural Determinants of Fullerene Binding. Acta Naturae. 2019 Jan-Mar;11(1):58-65. PMID:31024749

1 Structural highlights
2 Publication Abstract from PubMed
3 See Also
4 References

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PDB ID 6h3h

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Categories: Large Structures | Mus musculus | Osipov EM | Tikhonova TV

6h3h

From Proteopedia

Fab fragment of antibody against fullerene C60

Structural highlights

Publication Abstract from PubMed

See Also

References

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