6hwk

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Glucosamine kinase (crystal form B)

Structural highlights

6hwk is a 4 chain structure with sequence from Streptacidiphilus jiangxiensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.688Å
Ligands:CL, MG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLCNK_STRJI Catalyzes the ATP-dependent phosphorylation of D-glucosamine (GlcN) to D-glucosamine 6-phosphate. May be involved in the phosphorylation of acquired extracellular GlcN derived from the hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN into the bacterial GlcNAc metabolism. To a lesser extent, is also active on glucose, but is unable to phosphorylate maltose, 18 other sugars and several aminoglycoside antibiotics.[1]

References

  1. Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB. Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity. MBio. 2019 May 14;10(3). pii: mBio.00239-19. doi: 10.1128/mBio.00239-19. PMID:31088917 doi:http://dx.doi.org/10.1128/mBio.00239-19

Contents


PDB ID 6hwk

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