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Publication Abstract from PubMed

Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development.

Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.