6ke4
From Proteopedia
ABloop reengineered Ferritin Nanocage
Structural highlights
FunctionFRIH_HUMAN Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Publication Abstract from PubMedHuman ferritin has been explored as a potential drug nanocarrier, but extreme conditions (pH </= 2.0) are required for the encapsulation of drugs. Here, by engineering the AB loop of ferritin, we obtained a new ferritin variant with no new pores, which can disassemble at pH 3.0 or 4.0 and reassemble at pH 7.0. Consequently, under mild conditions, drugs can be encapsulated within this new ferritin nanocage. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.,Wang W, Wang L, Li G, Zhao G, Zhao X, Wang H Chem Commun (Camb). 2019 Oct 10;55(82):12344-12347. doi: 10.1039/c9cc05247j. PMID:31556881[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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