6myi

Structural highlights

Function

OLYA6_PLEOS Has hemolytic activity against bovine erythrocytes at nanomolar concentrations in vitro. Promotes active pleurotolysin B (PlyB)-dependent permeabilization of membranes rich in cholesterol and sphingomyelin. May play an important role in the initial phase of fungal fruiting.^{[1] [2]}

References

1. ↑ Berne S, Krizaj I, Pohleven F, Turk T, Macek P, Sepcic K. Pleurotus and Agrocybe hemolysins, new proteins hypothetically involved in fungal fruiting. Biochim Biophys Acta. 2002 Apr 15;1570(3):153-9. PMID:12020804
2. ↑ Ota K, Leonardi A, Mikelj M, Skocaj M, Wohlschlager T, Kunzler M, Aebi M, Narat M, Krizaj I, Anderluh G, Sepcic K, Macek P. Membrane cholesterol and sphingomyelin, and ostreolysin A are obligatory for pore-formation by a MACPF/CDC-like pore-forming protein, pleurotolysin B. Biochimie. 2013 Oct;95(10):1855-64. doi: 10.1016/j.biochi.2013.06.012. Epub 2013 , Jun 25. PMID:23806422 doi:http://dx.doi.org/10.1016/j.biochi.2013.06.012