6nom

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NMR solution structure of Pisum sativum defensin 2 (Psd2) provides evidence for the presence of hydrophobic surface clusters

Structural highlights

6nom is a 1 chain structure with sequence from Pisum sativum. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DEF2_PEA Possesses antifungal activity sensitive to inorganic cations.

Publication Abstract from PubMed

Pisum sativum defensin 2 (Psd2) is a small (4.7 kDa) antifungal peptide whose structure is held together by four conserved disulfide bridges. Psd2 shares the cysteine-stabilized alpha-beta (CSalphabeta) fold, which lacks a regular hydrophobic core. All hydrophobic residues are exposed to the surface, except for leucine 6. They are clustered in the surface formed by two loops, between beta1 and alpha-helix and beta2 and beta3 sheets. The observation of surface hydrophobic clusters reveals a remarkable evolution of the CSalphabeta fold to expose and reorganize hydrophobic residues, which facilitates creating versatile binding sites.

Nuclear magnetic resonance solution structure of Pisum sativum defensin 2 provides evidence for the presence of hydrophobic surface-clusters.,Pinheiro-Aguiar R, do Amaral VSG, Pereira IB, Kurtenbach E, Almeida FCL Proteins. 2019 Jul 11. doi: 10.1002/prot.25783. PMID:31294889[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction.
Vasconcelos et al. (2021)
2 more
3 other articles
No citations found

See Also

References

  1. ↑ Pinheiro-Aguiar R, do Amaral VSG, Pereira IB, Kurtenbach E, Almeida FCL. Nuclear magnetic resonance solution structure of Pisum sativum defensin 2 provides evidence for the presence of hydrophobic surface-clusters. Proteins. 2019 Jul 11. doi: 10.1002/prot.25783. PMID:31294889 doi:http://dx.doi.org/10.1002/prot.25783

Contents


PDB ID 6nom

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OCA

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