Structural highlights
Function
PLTF_PSEF5 Involved in the biosynthesis of pyoluteorin. Catalyzes the conversion of L-proline to L-prolyl-AMP and the transfer of the L-prolyl group to acyl carrier protein PltL.[1]
Publication Abstract from PubMed
Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.
Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis.,Corpuz JC, Podust LM, Davis TD, Jaremko MJ, Burkart MD RSC chem biol. 2020 Apr 1;1(1):8-12. doi: 10.1039/c9cb00015a. Epub 2020 Mar 24. PMID:33305272[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Thomas MG, Burkart MD, Walsh CT. Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem Biol. 2002 Feb;9(2):171-84. doi: 10.1016/s1074-5521(02)00100-x. PMID:11880032 doi:http://dx.doi.org/10.1016/s1074-5521(02)00100-x
- ↑ Corpuz JC, Podust LM, Davis TD, Jaremko MJ, Burkart MD. Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis. RSC chem biol. 2020 Apr 1;1(1):8-12. doi: 10.1039/c9cb00015a. Epub 2020 Mar 24. PMID:33305272 doi:http://dx.doi.org/10.1039/c9cb00015a
