6p7d

From Proteopedia

D104N S. typhimurium siroheme synthase

Structural highlights

6p7d is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Ligands:	CL, SAH
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CYSG_SALTY Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.^[1]

References

↑ Stroupe ME, Leech HK, Daniels DS, Warren MJ, Getzoff ED. CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. Nat Struct Biol. 2003 Dec;10(12):1064-73. Epub 2003 Nov 2. PMID:14595395 doi:10.1038/nsb1007

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 6p7d

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Categories: Large Structures | Salmonella enterica subsp. enterica serovar Typhimurium | Pennington JM | Stroupe ME

6p7d

From Proteopedia

D104N S. typhimurium siroheme synthase

Structural highlights

Function

See Also

References

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