6pfk

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PHOSPHOFRUCTOKINASE, INHIBITED T-STATE

Structural highlights

6pfk is a 4 chain structure with sequence from Geobacillus stearothermophilus. This structure supersedes the now removed PDB entry 5pfk. The February 2004 RCSB PDB Molecule of the Month feature on The Glycolytic Enzymes by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:PGA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PFKA_GEOSE Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_00339][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Byrnes M, Zhu X, Younathan ES, Chang SH. Kinetic characteristics of phosphofructokinase from Bacillus stearothermophilus: MgATP nonallosterically inhibits the enzyme. Biochemistry. 1994 Mar 22;33(11):3424-31. doi: 10.1021/bi00177a036. PMID:8136379 doi:http://dx.doi.org/10.1021/bi00177a036

Contents


PDB ID 6pfk

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