6ry3

Structural highlights

Function

WUS_ARATH Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expression of its own repressor, the AGAMOUS (AG) gene at the end of flower development. Binds directly to the 5'-TTAAT[GC][GC]-3' DNA sequence in the regulatory sequence of AG and activates its expression directly. Regulates one important step in ovule development to induce integument formation from the underlying chalazal domain. Participates in the promotion of vegetative to embryonic transition. Required to repress LEC1 expression.^{[1] [2] [3] [4] [5] [6] [7] [8] [9] [10]}

References

1. ↑ Schoof H, Lenhard M, Haecker A, Mayer KF, Jurgens G, Laux T. The stem cell population of Arabidopsis shoot meristems in maintained by a regulatory loop between the CLAVATA and WUSCHEL genes. Cell. 2000 Mar 17;100(6):635-44. doi: 10.1016/s0092-8674(00)80700-x. PMID:10761929 doi:http://dx.doi.org/10.1016/s0092-8674(00)80700-x
2. ↑ Lohmann JU, Hong RL, Hobe M, Busch MA, Parcy F, Simon R, Weigel D. A molecular link between stem cell regulation and floral patterning in Arabidopsis. Cell. 2001 Jun 15;105(6):793-803. doi: 10.1016/s0092-8674(01)00384-1. PMID:11440721 doi:http://dx.doi.org/10.1016/s0092-8674(01)00384-1
3. ↑ Lenhard M, Bohnert A, Jurgens G, Laux T. Termination of stem cell maintenance in Arabidopsis floral meristems by interactions between WUSCHEL and AGAMOUS. Cell. 2001 Jun 15;105(6):805-14. PMID:11440722
4. ↑ Zuo J, Niu QW, Frugis G, Chua NH. The WUSCHEL gene promotes vegetative-to-embryonic transition in Arabidopsis. Plant J. 2002 May;30(3):349-59. PMID:12000682
5. ↑ Gross-Hardt R, Lenhard M, Laux T. WUSCHEL signaling functions in interregional communication during Arabidopsis ovule development. Genes Dev. 2002 May 1;16(9):1129-38. doi: 10.1101/gad.225202. PMID:12000795 doi:http://dx.doi.org/10.1101/gad.225202
6. ↑ Brand U, Grunewald M, Hobe M, Simon R. Regulation of CLV3 expression by two homeobox genes in Arabidopsis. Plant Physiol. 2002 Jun;129(2):565-75. doi: 10.1104/pp.001867. PMID:12068101 doi:http://dx.doi.org/10.1104/pp.001867
7. ↑ Lenhard M, Jurgens G, Laux T. The WUSCHEL and SHOOTMERISTEMLESS genes fulfil complementary roles in Arabidopsis shoot meristem regulation. Development. 2002 Jul;129(13):3195-206. PMID:12070094
8. ↑ Gallois JL, Woodward C, Reddy GV, Sablowski R. Combined SHOOT MERISTEMLESS and WUSCHEL trigger ectopic organogenesis in Arabidopsis. Development. 2002 Jul;129(13):3207-17. PMID:12070095
9. ↑ Gallois JL, Nora FR, Mizukami Y, Sablowski R. WUSCHEL induces shoot stem cell activity and developmental plasticity in the root meristem. Genes Dev. 2004 Feb 15;18(4):375-80. doi: 10.1101/gad.291204. PMID:15004006 doi:http://dx.doi.org/10.1101/gad.291204
10. ↑ Mayer KF, Schoof H, Haecker A, Lenhard M, Jurgens G, Laux T. Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem. Cell. 1998 Dec 11;95(6):805-15. PMID:9865698