6wsb

From Proteopedia

Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomallei bound to cofactor NAD

PDB ID 6wsb

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Structural highlights

6wsb is a 2 chain structure with sequence from Burkholderia pseudomallei 1710b. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.55Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BETB_BURP1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.[HAMAP-Rule:MF_00804]

Publication Abstract from PubMed

Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.

Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.,Beard DK, Subramanian S, Abendroth J, Dranow DM, Edwards TE, Myler PJ, Asojo OA Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):45-51. doi:, 10.1107/S2053230X21013455. Epub 2022 Jan 27. PMID:35102892^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Beard DK, Subramanian S, Abendroth J, Dranow DM, Edwards TE, Myler PJ, Asojo OA. Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei. Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):45-51. doi:, 10.1107/S2053230X21013455. Epub 2022 Jan 27. PMID:35102892 doi:http://dx.doi.org/10.1107/S2053230X21013455