6x8l

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Caspase-7 in complex with elongated ketomethylene inhibitor

Structural highlights

6x8l is a 6 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.45Å
Ligands:ACE, Y2Y
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CASP7_HUMAN Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Contents


PDB ID 6x8l

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OCA

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