6xvx

From Proteopedia

X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)

Structural highlights

6xvx is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.4Å
Ligands:	ACT, RH3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RNAS1_BOVIN Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.^[1]

Publication Abstract from PubMed

The interactions between the cytotoxic paddlewheel dirhodium complex [Rh2(mu-O2CCH3)4] and the model protein bovine pancreatic ribonuclease (RNase A) were investigated by high-resolution mass spectrometry and X-ray crystallography. The results indicate that [Rh2(mu-O2CCH3)4] extensively reacts with RNase A. The metal compound binds the protein via coordination of the imidazole ring of a His side chain to one of its axial sites, while the dirhodium center and the acetato ligands remain unmodified. Data provide valuable information for the design of artificial dirhodium-containing metalloenzymes.

Protein interactions of dirhodium tetraacetate: a structural study.,Ferraro G, Pratesi A, Messori L, Merlino A Dalton Trans. 2020 Feb 5. doi: 10.1039/c9dt04819g. PMID:32022076^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

1 reviews cite this structure

Diruthenium Paddlewheel Complexes Attacking Proteins: Axial versus Equatorial Coordination.

Tolbatov et al. (2024)

0 more

8 other articles

No citations found

References

↑ delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688
↑ Ferraro G, Pratesi A, Messori L, Merlino A. Protein interactions of dirhodium tetraacetate: a structural study. Dalton Trans. 2020 Feb 5. doi: 10.1039/c9dt04819g. PMID:32022076 doi:http://dx.doi.org/10.1039/c9dt04819g

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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PDB ID 6xvx

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Categories: Bos taurus | Large Structures | Ferraro G | Merlino A

6xvx

From Proteopedia

X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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