6yym
From Proteopedia
Structure of S. pombe Mei2 RRM3 domain bound to RNA
Structural highlights
FunctionMEI2_SCHPO Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. Publication Abstract from PubMedLong non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in response to intra- or extracellular signals but the underlying molecular mechanisms remain largely unexplored. Here, we identify an uncharacterized lncRNA as a central player in shaping the meiotic gene expression program in fission yeast. We report that this regulatory RNA, termed mamRNA, scaffolds the antagonistic RNA-binding proteins Mmi1 and Mei2 to ensure their reciprocal inhibition and fine tune meiotic mRNA degradation during mitotic growth. Mechanistically, mamRNA allows Mmi1 to target Mei2 for ubiquitin-mediated downregulation, and conversely enables accumulating Mei2 to impede Mmi1 activity, thereby reinforcing the mitosis to meiosis switch. These regulations also occur within a unique Mmi1-containing nuclear body, positioning mamRNA as a spatially-confined sensor of Mei2 levels. Our results thus provide a mechanistic basis for the mutual control of gametogenesis effectors and further expand our vision of the regulatory potential of lncRNAs. A scaffold lncRNA shapes the mitosis to meiosis switch.,Andric V, Nevers A, Hazra D, Auxilien S, Menant A, Graille M, Palancade B, Rougemaille M Nat Commun. 2021 Feb 3;12(1):770. doi: 10.1038/s41467-021-21032-7. PMID:33536434[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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