7a0c

From Proteopedia

X-ray structure of NikA from Escherichia coli in complex with Fe-6-Me2-BPMCN

Structural highlights

7a0c is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	ACT, CL, FE, GOL, MG, QTT
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NIKA_ECOLI Involved in a nickel transport system, probably represents the nickel binder.

Publication Abstract from PubMed

Performing a heterogeneous catalysis with proteins is still a challenge. Here, we demonstrate the importance of cross-linked crystals for sulfoxide oxidation by an artificial enzyme. The biohybrid consists of the insertion of an iron complex into a NikA protein crystal. The heterogeneous catalysts displays a better efficiency-with higher reaction kinetics, a better stability and expand the substrate scope compared to its solution counterpart. Designing crystalline artificial enzymes represents a good alternative to soluble or supported enzymes for the future of synthetic biology.

A Selective Sulfide Oxidation catalyzed by Heterogeneous Artificial Enzymes Iron@NikA.,Menage S, Lopez S, Marchi-Delapierre C, Cavazza C Chemistry. 2020 Oct 20. doi: 10.1002/chem.202003746. PMID:33079395^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

1 reviews cite this structure

Designing Artificial Metalloenzymes by Tuning of the Environment beyond the Primary Coordination Sphere.

Van et al. (2022)

0 more

0 other articles

No citations found

References

↑ Menage S, Lopez S, Marchi-Delapierre C, Cavazza C. A Selective Sulfide Oxidation catalyzed by Heterogeneous Artificial Enzymes Iron@NikA. Chemistry. 2020 Oct 20. doi: 10.1002/chem.202003746. PMID:33079395 doi:http://dx.doi.org/10.1002/chem.202003746

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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PDB ID 7a0c

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Categories: Escherichia coli K-12 | Large Structures | Cavazza C | Menage S

7a0c

From Proteopedia

X-ray structure of NikA from Escherichia coli in complex with Fe-6-Me2-BPMCN

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

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