7bp3

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Cryo-EM structure of the human MCT2

Structural highlights

7bp3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MOT2_HUMAN Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:9786900, PubMed:32415067). Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067).[1] [2]

References

  1. ↑ Zhang B, Jin Q, Xu L, Li N, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N, Zhang X, Yang F, Guo J, Ye S. Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun. 2020 May 15;11(1):2429. PMID:32415067 doi:10.1038/s41467-020-16334-1
  2. ↑ Lin RY, Vera JC, Chaganti RS, Golde DW. Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. PMID:9786900 doi:10.1074/jbc.273.44.28959

Contents


PDB ID 7bp3

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OCA

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