7ddu

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Elephant seal myoglobin esMb

Structural highlights

7ddu is a 2 chain structure with sequence from Mirounga angustirostris. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:HEM, SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

R9S002_MIRAN Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.[ARBA:ARBA00002755][RuleBase:RU251113]

Publication Abstract from PubMed

Myoglobin (Mb) is highly concentrated in the myocytes of diving mammals such as whales and seals, in comparison with land animals, and its molecular evolution has played a crucial role in their deep-sea adaptation. We previously resurrected ancestral whale Mbs and demonstrated the evolutional strategies for higher solubility under macromolecular crowding conditions. Pinnipeds, such as seals and sea lions, are also expert diving mammals with Mb-rich muscles. In the present study, we resurrected ancestral pinniped Mbs and investigated their biochemical and structural properties. Comparisons between pinniped and whale Mbs revealed the common and distinctive strategies for the deep-sea adaptation. The overall evolution processes, gaining precipitant tolerance and improving thermodynamic stability, were commonly observed. However, the strategies for improving the folding stability differed, and the pinniped Mbs exploited the shielding of hydrophobic surfaces more effectively than the whale Mbs.

Common and unique strategies of myoglobin evolution for deep-sea adaptation of diving mammals.,Isogai Y, Imamura H, Nakae S, Sumi T, Takahashi KI, Shirai T iScience. 2021 Jul 30;24(8):102920. doi: 10.1016/j.isci.2021.102920. eCollection , 2021 Aug 20. PMID:34430810[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
0 reviews cite this structure
Comparative analysis of the myoglobin gene in whales and humans reveals evolutionary changes in regulatory elements and expression levels.
Sackerson et al. (2023)
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1 other articles
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See Also

References

  1. ↑ Isogai Y, Imamura H, Nakae S, Sumi T, Takahashi KI, Shirai T. Common and unique strategies of myoglobin evolution for deep-sea adaptation of diving mammals. iScience. 2021 Jul 30;24(8):102920. PMID:34430810 doi:10.1016/j.isci.2021.102920

Contents


PDB ID 7ddu

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OCA

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