7kgq

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Crystal Structure of HLA-A*0201in complex with SARS-CoV-2 N222-230

Structural highlights

7kgq is a 3 chain structure with sequence from Homo sapiens and Severe acute respiratory syndrome coronavirus 2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.34Å
Ligands:CA, CD, EDO
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q861F7_HUMAN

Publication Abstract from PubMed

CD8+ T cells are crucial for anti-viral immunity; however, understanding T cell responses requires the identification of epitopes presented by human leukocyte antigens (HLA). To date, few SARS-CoV-2-specific CD8+ T cell epitopes have been described. Internal viral proteins are typically more conserved than surface proteins and are often the target of CD8+ T cells. Therefore, we have characterized eight peptides derived from the internal SARS-CoV-2 nucleocapsid protein predicted to bind HLA-A( *)02:01, the most common HLA molecule in the global population. We determined not all peptides could form a complex with HLA-A( *)02:01, and the six crystal structures determined revealed that some peptides adopted a mobile conformation. We therefore provide a molecular understanding of SARS-CoV-2 CD8+ T cell epitopes. Furthermore, we show that there is limited pre-existing CD8+ T cell response toward these epitopes in unexposed individuals. Together, these data show that SARS-CoV-2 nucleocapsid might not contain potent epitopes restricted to HLA-A( *)02:01.

The presentation of SARS-CoV-2 peptides by the common HLA-A( *)02:01 molecule.,Szeto C, Chatzileontiadou DSM, Nguyen AT, Sloane H, Lobos CA, Jayasinghe D, Halim H, Smith C, Riboldi-Tunnicliffe A, Grant EJ, Gras S iScience. 2021 Feb 19;24(2):102096. doi: 10.1016/j.isci.2021.102096. Epub 2021 , Jan 22. PMID:33521593[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
Nguyen et al. (2021)
No citations found

See Also

References

  1. Szeto C, Chatzileontiadou DSM, Nguyen AT, Sloane H, Lobos CA, Jayasinghe D, Halim H, Smith C, Riboldi-Tunnicliffe A, Grant EJ, Gras S. The presentation of SARS-CoV-2 peptides by the common HLA-A(∗)02:01 molecule. iScience. 2021 Feb 19;24(2):102096. PMID:33521593 doi:10.1016/j.isci.2021.102096

Contents


PDB ID 7kgq

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