7kqg

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Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses

Structural highlights

7kqg is a 3 chain structure with sequence from Homo sapiens and Influenza B virus (B/Florida/4/2006). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:BMA, MAN, NAG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.

Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.,Bajic G, Harrison SC ACS Infect Dis. 2021 Jan 8;7(1):1-5. doi: 10.1021/acsinfecdis.0c00726. Epub 2020 , Dec 4. PMID:33274930[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Bajic G, Harrison SC. Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses. ACS Infect Dis. 2021 Jan 8;7(1):1-5. PMID:33274930 doi:10.1021/acsinfecdis.0c00726

Contents


PDB ID 7kqg

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