7lfy

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Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+

Structural highlights

7lfy is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.6Å
Ligands:NA, PCG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

CNGA1_HUMAN Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry.

Function

CNGA1_HUMAN Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194]

See Also

Contents


PDB ID 7lfy

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OCA

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