Structural highlights
Disease
CNGA1_HUMAN Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry.
Function
CNGA1_HUMAN Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194]
See Also