7n3y

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Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain E59Q/D222N Mutant in Complex with DNA

Structural highlights

7n3y is a 8 chain structure with sequence from Saccharomyces cerevisiae and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.73Å
Ligands:AS, CA, CIT, EDO, GS, PST, SC, TAR, TLA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

APN2_YEAST DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.[1] [2]

See Also

References

  1. ↑ Unk I, Haracska L, Johnson RE, Prakash S, Prakash L. Apurinic endonuclease activity of yeast Apn2 protein. J Biol Chem. 2000 Jul 21;275(29):22427-34. PMID:10806210 doi:http://dx.doi.org/10.1074/jbc.M002845200
  2. ↑ Johnson RE, Torres-Ramos CA, Izumi T, Mitra S, Prakash S, Prakash L. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev. 1998 Oct 1;12(19):3137-43. doi: 10.1101/gad.12.19.3137. PMID:9765213 doi:http://dx.doi.org/10.1101/gad.12.19.3137

Contents


PDB ID 7n3y

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OCA

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