Structural highlights
Function
ITPK4_ARATH Kinase that can phosphorylate the inositol polyphosphate Ins(1,3,4)P3 to form InsP4. Also phosphorylates a racemic mixture of Ins(1,4,6)P3 and Ins(3,4,6)P3 to form InsP4. Does not display inositol 3,4,5,6-tetrakisphosphate 1-kinase activity, but possesses inositol 1,4,5,6-tetrakisphosphate and inositol 1,3,4,5-tetrakisphosphate isomerase activity (PubMed:17698066). Ins(1,3,4,6)P4 is an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity).[UniProtKB:Q13572][1]
References
- ↑ Sweetman D, Stavridou I, Johnson S, Green P, Caddick SE, Brearley CA. Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis. FEBS Lett. 2007 Sep 4;581(22):4165-71. PMID:17698066 doi:10.1016/j.febslet.2007.07.046
