Structural highlights
Function
RADD_ECOLI May be a helicase. In combination with RadA is important in repair of double-strand DNA breaks (DSB) (PubMed:25425430, PubMed:25484163).[1] [2]
Publication Abstract from PubMed
Genome maintenance is an essential process in all cells. In prokaryotes, the RadD protein is important for survival under conditions that include DNA-damaging radiation. Precisely how RadD participates in genome maintenance remains unclear. Here we present a high-resolution X-ray crystal structure of ADP-bound Escherichia coli RadD, revealing a zinc-ribbon element that was not modelled in a previous RadD crystal structure. Insights into the mode of nucleotide binding and additional structure refinement afforded by the new RadD model will help to drive investigations into the activity of RadD as a genome stability and repair factor.
X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain.,Osorio Garcia MA, Satyshur KA, Cox MM, Keck JL PLoS One. 2022 Apr 28;17(4):e0266031. doi: 10.1371/journal.pone.0266031., eCollection 2022. PMID:35482735[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Chen SH, Byrne RT, Wood EA, Cox MM. Escherichia coli radD (yejH) gene: a novel function involved in radiation resistance and double-strand break repair. Mol Microbiol. 2015 Mar;95(5):754-68. doi: 10.1111/mmi.12885. Epub 2015 Jan 16. PMID:25425430 doi:http://dx.doi.org/10.1111/mmi.12885
- ↑ Cooper DL, Boyle DC, Lovett ST. Genetic analysis of Escherichia coli RadA: functional motifs and genetic interactions. Mol Microbiol. 2015 Mar;95(5):769-79. doi: 10.1111/mmi.12899. Epub 2015 Jan 30. PMID:25484163 doi:http://dx.doi.org/10.1111/mmi.12899
- ↑ Osorio Garcia MA, Satyshur KA, Cox MM, Keck JL. X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain. PLoS One. 2022 Apr 28;17(4):e0266031. doi: 10.1371/journal.pone.0266031., eCollection 2022. PMID:35482735 doi:http://dx.doi.org/10.1371/journal.pone.0266031
