7ulr

Structural highlights

Function

3LKB_BUNMU Postsynaptic neurotoxin that binds and inhibits neuronal nicotinic acetylcholine receptors (nAChR) with high affinity (IC(50)<100 nM). Is a selective, and slowly reversible antagonist of alpha-3/CHRNA3-containing and some alpha-4/CHRNA4-containing AChRs.^{[1] [2]}

References

1. ↑ Grant GA, Chiappinelli VA. kappa-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe. Biochemistry. 1985 Mar 12;24(6):1532-7. PMID:3986193
2. ↑ Chiappinelli VA, Weaver WR, McLane KE, Conti-Fine BM, Fiordalisi JJ, Grant GA. Binding of native kappa-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors. Toxicon. 1996 Nov-Dec;34(11-12):1243-56. PMID:9027980 doi:10.1016/s0041-0101(96)00110-9