7yzb

From Proteopedia

Crystal structure of the human FoxH1 bound to the TGTGGATT site

Structural highlights

7yzb is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.47Å
Ligands:	K
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

FOXH1_HUMAN Septopreoptic holoprosencephaly;Semilobar holoprosencephaly;Lobar holoprosencephaly;Alobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly;Microform holoprosencephaly.

Function

FOXH1_HUMAN Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).^[1]

References

↑ Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B. Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul;2(1):121-7. doi: 10.1016/s1097-2765(00)80120-3. PMID:9702198 doi:http://dx.doi.org/10.1016/s1097-2765(00)80120-3

1 Structural highlights
2 Disease
3 Function
4 See Also
5 References

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PDB ID 7yzb

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Categories: Homo sapiens | Large Structures | Macias MJ | Pluta R

7yzb

From Proteopedia

Crystal structure of the human FoxH1 bound to the TGTGGATT site

Structural highlights

Disease

Function

See Also

References

Contents

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