8-Oxoguanine Glycosylase

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Human 8-oxoguanine glycosylate complex with oxoguanine-containing DNA and Ca+2 ion (PDB code 1yqr)


1. Klaunig JE, Kamendulis LM (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44: 239-267.

2. Lindahl T (1993) Instability and decay of the primary structure of DNA. Nature 362: 709-715.

3. David SS, O'Shea VL, Kundu S (2007) Base-excision repair of oxidative DNA damage. Nature 447: 941-950.

4. Neeley WL, Essigmann JM (2006) Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem Res Toxicol 19: 491-505.

5. Scharer OD, Jiricny J (2001) Recent progress in the biology, chemistry and structural biology of DNA glycosylases. Bioessays 23: 270-281.

6. Bruner SD, Norman DP, Verdine GL (2000) Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature 403: 859-866.

7. Michaels ML, Miller JH (1992) The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J Bacteriol 174: 6321-6325.

8. Barnes DE, Lindahl T (2004) Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet 38: 445-476.

9. Hegde ML, Hazra TK, Mitra S (2008) Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res 18: 27-47.

10. Monden Y, Arai T, Asano M, Ohtsuka E, Aburatani H, et al. (1999) Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells. Biochem Biophys Res Commun 258: 605-610.

11. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 447: 447-452.

12. Jarem DA, Wilson NR, Delaney S (2009) Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. Biochemistry 48: 6655-6663.

13. Lu J, Liu Y (2010) Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast. EMBO J 29: 398-409.

14. Tsuzuki T, Nakatsu Y, Nakabeppu Y (2007) Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. Cancer Sci 98: 465-470.

15. Paz-Elizur T, Sevilya Z, Leitner-Dagan Y, Elinger D, Roisman LC, et al. (2008) DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention. Cancer Lett 266: 60-72.

16. Minowa O, Arai T, Hirano M, Monden Y, Nakai S, et al. (2000) Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A 97: 4156-4161.

17. Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, et al. (1999) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A 96: 13300-13305.

18. Sakumi K, Tominaga Y, Furuichi M, Xu P, Tsuzuki T, et al. (2003) Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res 63: 902-905.

19. Chevillard S, Radicella JP, Levalois C, Lebeau J, Poupon MF, et al. (1998) Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. Oncogene 16: 3083-3086.

20. Stivers JT (2004) Site-specific DNA damage recognition by enzyme-induced base flipping. Prog Nucleic Acid Res Mol Biol 77: 37-65.

21. Banerjee A, Yang W, Karplus M, Verdine GL (2005) Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature 434: 612-618.

22. Nash HM, Lu R, Lane WS, Verdine GL (1997) The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution. Chem Biol 4: 693-702.

23. van der Kemp PA, Charbonnier JB, Audebert M, Boiteux S (2004) Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket. Nucleic Acids Res 32: 570-578.

24. Guibourt N, Castaing B, Van Der Kemp PA, Boiteux S (2000) Catalytic and DNA binding properties of the ogg1 protein of Saccharomyces cerevisiae: comparison between the wild type and the K241R and K241Q active-site mutant proteins. Biochemistry 39: 1716-1724.

25. Bjoras M, Luna L, Johnsen B, Hoff E, Haug T, et al. (1997) Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites. EMBO J 16: 6314-6322.

26. Nash HM, Bruner SD, Scharer OD, Kawate T, Addona TA, et al. (1996) Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol 6: 968-980.

27. Zharkov DO, Rosenquist TA, Gerchman SE, Grollman AP (2000) Substrate specificity and reaction mechanism of murine 8-oxoguanine-DNA glycosylase. J Biol Chem 275: 28607-28617.

28. Dodson ML, Schrock RD, 3rd, Lloyd RS (1993) Evidence for an imino intermediate in the T4 endonuclease V reaction. Biochemistry 32: 8284-8290.

29. Dodson ML, Michaels ML, Lloyd RS (1994) Unified catalytic mechanism for DNA glycosylases. J Biol Chem 269: 32709-32712.

30. Scharer OD, Deng L, Verdine GL (1997) Chemical approaches toward understanding base excision DNA repair. Curr Opin Chem Biol 1: 526-531.

31. Dodson ML, Lloyd RS (2002) Mechanistic comparisons among base excision repair glycosylases. Free Radic Biol Med 32: 678-682.

32. Labahn J, Scharer OD, Long A, Ezaz-Nikpay K, Verdine GL, et al. (1996) Structural basis for the excision repair of alkylation-damaged DNA. Cell 86: 321-329. 33. Tchou J, Grollman AP (1995) The catalytic mechanism of Fpg protein. Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site. J Biol Chem 270: 11671-11677.

Additional Resources

For additional information, see: Cancer


  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Lu AL, Li X, Gu Y, Wright PM, Chang DY. Repair of oxidative DNA damage: mechanisms and functions. Cell Biochem Biophys. 2001;35(2):141-70. PMID:11892789 doi:10.1385/CBB:35:2:141
  2. 2.0 2.1 Bruner SD, Norman DP, Verdine GL. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature. 2000 Feb 24;403(6772):859-66. PMID:10706276 doi:10.1038/35002510
  3. Cappelli E, Hazra T, Hill JW, Slupphaug G, Bogliolo M, Frosina G. Rates of base excision repair are not solely dependent on levels of initiating enzymes. Carcinogenesis. 2001 Mar;22(3):387-93. PMID:11238177
  4. 4.0 4.1 Banerjee A, Yang W, Karplus M, Verdine GL. Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature. 2005 Mar 31;434(7033):612-8. PMID:15800616 doi:10.1038/nature03458
  5. 5.0 5.1 5.2 Lingaraju GM, Sartori AA, Kostrewa D, Prota AE, Jiricny J, Winkler FK. A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure. Structure. 2005 Jan;13(1):87-98. PMID:15642264 doi:10.1016/j.str.2004.10.011
  6. Dodson ML, Schrock RD 3rd, Lloyd RS. Evidence for an imino intermediate in the T4 endonuclease V reaction. Biochemistry. 1993 Aug 17;32(32):8284-90. PMID:8347626

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