8amf

Structural highlights

Function

RECA_STRR6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs (By similarity). It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Required for DNA transformation; protects transforming DNA from degradation, possibly in combination with DprA (PubMed:14617176, PubMed:17803906). Present at 15,000-30,000 monomers per competent cell (PubMed:14617176).[HAMAP-Rule:MF_00268]^{[1] [2]}

References

1. ↑ Bergé M, Mortier-Barrière I, Martin B, Claverys JP. Transformation of Streptococcus pneumoniae relies on DprA protection of incoming DNA single strands. Mol Microbiol. 2003 Oct;50(2):527-36. PMID:14617176 doi:10.1046/j.1365-2958.2003.03702.x
2. ↑ Mortier-Barrière I, Velten M, Dupaigne P, Mirouze N, Piétrement O, McGovern S, Fichant G, Martin B, Noirot P, Le Cam E, Polard P, Claverys JP. A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA. Cell. 2007 Sep 7;130(5):824-36. PMID:17803906 doi:10.1016/j.cell.2007.07.038