Structural highlights
Function
DACA_LISMO Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes.[1]
References
- ↑ Woodward JJ, Iavarone AT, Portnoy DA. c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science. 2010 Jun 25;328(5986):1703-5. doi: 10.1126/science.1189801. Epub 2010, May 27. PMID:20508090 doi:http://dx.doi.org/10.1126/science.1189801
