8dja

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Cryo-EM structure of mouse PrP23-144 amyloid fibrils (polymorph 1)

Structural highlights

8dja is a 20 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.92Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

One of the least understood aspects of prion diseases is the structure of infectious prion protein aggregates. Here we report a high-resolution cryo-EM structure of amyloid fibrils formed by human prion protein with the Y145Stop mutation that is associated with a familial prion disease. This structural insight allows us not only to explain previous biochemical findings, but also provides direct support for the conformational adaptability model of prion transmissibility barriers.

Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers.,Li Q, Jaroniec CP, Surewicz WK Nat Struct Mol Biol. 2022 Oct;29(10):962-965. doi: 10.1038/s41594-022-00833-4. , Epub 2022 Sep 12. PMID:36097290[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
2 reviews cite this structure
Mechanisms and pathology of protein misfolding and aggregation.
Louros et al. (2023)
1 more
5 other articles
No citations found

See Also

References

  1. ↑ Li Q, Jaroniec CP, Surewicz WK. Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers. Nat Struct Mol Biol. 2022 Oct;29(10):962-965. PMID:36097290 doi:10.1038/s41594-022-00833-4

Contents


PDB ID 8dja

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OCA

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