8g02

Structural highlights

Function

MRAY_ECOLI Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.[HAMAP-Rule:MF_00038]^{[1] [2]}

See Also

• Peptidyl-prolyl cis-trans isomerase 3D structures

References

1. ↑ Ikeda M, Wachi M, Jung HK, Ishino F, Matsuhashi M. The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase. J Bacteriol. 1991 Feb;173(3):1021-6. PMID:1846850 doi:10.1128/jb.173.3.1021-1026.1991
2. ↑ Geis A, Plapp R. Phospho-N-acetylmuramoyl-pentapeptide-transferase of Escherichia coli K12. Properties of the membrane-bound and the extracted and partially purified enzyme. Biochim Biophys Acta. 1978 Dec 8;527(2):414-24. PMID:215212 doi:10.1016/0005-2744(78)90355-8