8hrx
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proteopedia linkproteopedia linkCryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
Structural highlights
DiseaseNTCP_HUMAN The disease is caused by variants affecting the gene represented in this entry. FunctionNTCP_HUMAN As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).[1] [2] (Microbial infection) Acts as a receptor for hepatitis B virus.[3] References
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