Structural highlights
Function
CDAA_BACSU One of 3 paralogous diadenylate cyclases (DAC) in this bacteria, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (Probable). Upon expression in E.coli leads to c-di-AMP synthesis (PubMed:23192352). Probably the main producer of c-di-AMP for the cell; is probably implicated in control of peptidogylcan synthesis (PubMed:22211522, PubMed:23192352, PubMed:26240071). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071).[1] [2] [3]
References
- ↑ Mehne FM, Gunka K, Eilers H, Herzberg C, Kaever V, Stülke J. Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth. J Biol Chem. 2013 Jan 18;288(3):2004-17. PMID:23192352 doi:10.1074/jbc.M112.395491
- ↑ Gundlach J, Mehne FM, Herzberg C, Kampf J, Valerius O, Kaever V, Stulke J. An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis. J Bacteriol. 2015 Oct;197(20):3265-74. doi: 10.1128/JB.00564-15. Epub 2015 Aug 3. PMID:26240071 doi:http://dx.doi.org/10.1128/JB.00564-15
- ↑ Luo Y, Helmann JD. Analysis of the role of Bacillus subtilis σ(M) in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis. Mol Microbiol. 2012 Feb;83(3):623-39. PMID:22211522 doi:10.1111/j.1365-2958.2011.07953.x
