8pbv

Structural highlights

Function

TOTA_DROME A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response.^{[1] [2] [3] [4]}

References

1. ↑ Ekengren S, Tryselius Y, Dushay MS, Liu G, Steiner H, Hultmark D. A humoral stress response in Drosophila. Curr Biol. 2001 May 1;11(9):714-8. PMID:11369236 doi:10.1016/s0960-9822(01)00203-2
2. ↑ Ekengren S, Hultmark D. A family of Turandot-related genes in the humoral stress response of Drosophila. Biochem Biophys Res Commun. 2001 Jun 22;284(4):998-1003. PMID:11409894 doi:10.1006/bbrc.2001.5067
3. ↑ Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003 Sep;5(3):441-50. PMID:12967563 doi:10.1016/s1534-5807(03)00244-2
4. ↑ Brun S, Vidal S, Spellman P, Takahashi K, Tricoire H, Lemaitre B. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Genes Cells. 2006 Apr;11(4):397-407. PMID:16611243 doi:10.1111/j.1365-2443.2006.00953.x