Structural highlights
Function
CHMU_PSEAE Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate.[UniProtKB:P0A9J8][1]
References
- ↑ Calhoun DH, Bonner CA, Gu W, Xie G, Jensen RA. The emerging periplasm-localized subclass of AroQ chorismate mutases, exemplified by those from Salmonella typhimurium and Pseudomonas aeruginosa. Genome Biol. 2001;2(8):RESEARCH0030. PMID:11532214 doi:10.1186/gb-2001-2-8-research0030