Structural highlights
Function
SIAT1_HAEIN Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid (N-acetyl-beta-neuraminate). N-Acetylneuraminate can then be incorporated into the lipopolysaccharides as a terminal non-reducing sugar, protecting the bacterium from complement-mediated killing by normal human serum.[1]
References
- ↑ Severi E, Randle G, Kivlin P, Whitfield K, Young R, Moxon R, Kelly D, Hood D, Thomas GH. Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter. Mol Microbiol. 2005 Nov;58(4):1173-85. PMID:16262798 doi:http://dx.doi.org/MMI4901
