8tl8

Structural highlights

Function

SIGNS_REOVD Protein that binds to ssRNA and participates with protein mu-NS in forming the matrix of viral factories, which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place (PubMed:11152519). Plays a role in the inhibition of the integrated stress response (ISR) to escape from host cell translational shutoff (PubMed:28794026). Participates in the disruption of stress granules (SG) through its association with host G3BP1 and mu-NS (PubMed:28794026).^{[1] [2]}

References

1. ↑ Becker MM, Goral MI, Hazelton PR, Baer GS, Rodgers SE, Brown EG, Coombs KM, Dermody TS. Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions. J Virol. 2001 Feb;75(3):1459-75. PMID:11152519 doi:10.1128/JVI.75.3.1459-1475.2001
2. ↑ Choudhury P, Bussiere LD, Miller CL. Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1. J Virol. 2017 Oct 13;91(21):e01298-17. PMID:28794026 doi:10.1128/JVI.01298-17