8va1

Structural highlights

Function

TARL_STAA8 Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of ribitol phosphate units from CDP-ribitol to the second glycerol phosphate attached to the disaccharide linkage unit. Synthesizes polymers of more than 40 ribitol phosphate units in length.^{[1] [2] [3]}

References

1. ↑ Brown S, Zhang YH, Walker S. A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps. Chem Biol. 2008 Jan;15(1):12-21. PMID:18215769 doi:10.1016/j.chembiol.2007.11.011
2. ↑ Pereira MP, D'Elia MA, Troczynska J, Brown ED. Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases. J Bacteriol. 2008 Aug;190(16):5642-9. PMID:18556787 doi:10.1128/JB.00526-08
3. ↑ Brown S, Meredith T, Swoboda J, Walker S. Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways. Chem Biol. 2010 Oct 29;17(10):1101-10. PMID:21035733 doi:10.1016/j.chembiol.2010.07.017