8vu5

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Cryo-EM structure of MPL bound to TPO

Structural highlights

8vu5 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.39Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TPO_MOUSE Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.[UniProtKB:P40225]

Contents


PDB ID 8vu5

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OCA

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