8woo

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Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state

Structural highlights

8woo is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.9Å
Ligands:ANP, BLD, MG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AB19B_ARATH Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues, and from root tips to root elongating zone). Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation.[1] [2] [3]

References

  1. Noh B, Murphy AS, Spalding EP. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. Plant Cell. 2001 Nov;13(11):2441-54. PMID:11701880 doi:10.1105/tpc.010350
  2. Geisler M, Kolukisaoglu HU, Bouchard R, Billion K, Berger J, Saal B, Frangne N, Koncz-Kalman Z, Koncz C, Dudler R, Blakeslee JJ, Murphy AS, Martinoia E, Schulz B. TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. Mol Biol Cell. 2003 Oct;14(10):4238-49. Epub 2003 Aug 7. PMID:14517332 doi:http://dx.doi.org/10.1091/mbc.E02-10-0698
  3. Lin R, Wang H. Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport. Plant Physiol. 2005 Jun;138(2):949-64. PMID:15908594 doi:10.1104/pp.105.061572

Contents


PDB ID 8woo

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