8x1w

Structural highlights

Function

T5H_TAXCU Catalyzes the first oxygenation step of taxol biosynthesis. Can use both taxa-4(5),11(12)-diene and taxa-4(20),11(12)-diene as substrate.^[1]

References

1. ↑ Jennewein S, Long RM, Williams RM, Croteau R. Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem Biol. 2004 Mar;11(3):379-87. PMID:15123267 doi:10.1016/j.chembiol.2004.02.022